Comment
Author: Admin | 2025-04-28
Infrequent occurrences. The assessment of drugs or ADEs based on RR is variable because of information that the RR methodology does not include, including underreported or overreported events. To assess the effect that the RR methodology has when a small number of ADE occurrences are compared to the whole database, the fifth percentiles from the lower confidence interval of EBGM (EB05) were used as a very conservative alternative, and the results are compared to RR. This assessment was performed using EBGM, is reported similar to the prevalence evaluation using RR values from above. The frequencies of a single drug having multiple ADEs in HLT groups or a single HLT ADE occurrence in multiple drugs were calculated. It was then found that the top 10 drugs with pulmonary ADEs consisted of AHAs, ATAs, and UAs. Bosentan, tadalafil, treprostinil, and beraprost based on EBGM were ranked substantially higher than their corresponding ranks when using RR, with respect to pulmonary ADEs. This suggests that the conservative, EBGM method with a fifth percentile cut-off will allow for the examination of large datasets of ADEs when high variability is present in the number of ADEs across drugs or drug classes, and still allow for a robust reporting methodology as compared to the RR methodology. This allows analysis of very large sets of drugs and ADEs (such as approximately 500,000×134 matrix here) without loss of sensitivity or imparting an over-emphasis on ADEs from infrequently prescribed drugs. GLASSO The total number of distinct drugs used by patients
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