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Author: Admin | 2025-04-28
MR, Walzer T, Belot A, Jamilloux Y, Henry T. Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients. EMBO Mol Med. 2019;11(11):e10547. https://doi.org/10.15252/emmm.201910547Article CAS PubMed PubMed Central Google Scholar Xu H, Yang J, Gao W, Li L, Li P, Zhang L, et al. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature. 2014;513:237–41.Article CAS PubMed Google Scholar Yu OM, Brown JH. G protein-coupled receptor and RhoA-stimulated transcriptional responses: links to inflammation, differentiation, and cell proliferation. Mol Pharmacol. 2015;88:171–80.Article CAS PubMed PubMed Central Google Scholar Aktories K. Bacterial protein toxins that modify host regulatory GTPases. Nat Rev Microbiol. 2011;9:487–98.Article CAS PubMed Google Scholar Chan AH, Schroder K. Inflammasome signaling and regulation of interleukin-1 family cytokines. J Exp Med. 2020;217(1):e20190314. https://doi.org/10.1084/jem.20190314Article CAS PubMed Google Scholar Park YH, Wood G, Kastner DL, Chae JJ. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914–21.Article CAS PubMed PubMed Central Google Scholar Zverina EA, Lamphear CL, Wright EN, Fierke CA. Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions. Curr Opin Chem Biol. 2012;16:544–52.Article CAS PubMed PubMed Central Google Scholar Gao W, Yang J, Liu W, Wang Y, Shao F. Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation. Proc Natl Acad Sci U S A. 2016;113:E4857–66.Article CAS PubMed PubMed Central Google Scholar Obsil T, Obsilova V. Structural basis of 14-3-3 protein functions. Semin Cell Dev Biol. 2011;22:663–72.Article CAS PubMed Google Scholar Jéru I, Papin S, L'Hoste S,
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